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Characterizing the Target of Acute Stroke Therapy Stroke 28:866-872, Fisher,M., 1997 See this aricle in Pubmed Article Abstract Pathological identification of irreversibility(infarction)appears to lag behind the actual development of this condition,and reversible injury after focal ischemia should be differentiated from infarction.Imaging and biochemical markers apparently can provide clues for distinguishing potentially salvageable from irreversibly injured ischemic tissue in experimental and clinical stroke.Recent positron emission tomography and MRI studies suggest that these clinically available imaging technologies will be useful for determining the presence of ischemic penumbra in individual stroke patients.The progression from potentially reversible to irreversible injury after focal brain ischemia has many potential mechanisms that may be synergistic and vary among individuals.Delineating and prioritizing these mechanisms provides the opportunity to develop multiple potential acute stroke therapies that ultimately will be used in combination,perhaps directed by imaging technology.

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(click to filter results - removes previous filter) CAT scan,emission,abnormal cerebral ischemia cerebrovascular accident cerebrovascular accident,acute management of cerebrovascular accident,pathophysiology ischemic penumbra MRI MRI,abnormal MRI,diffusion weighted MRI,early changes in CVA neuroprotective agents treatment of neurologic disorder

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